RAD-140 was developed by Radius Pharmaceuticals in the late 2000s as a potential therapeutic aid to prevent muscle wasting in terminally ill patients. It’s currently being researched as a therapeutic aid for breast cancer patients. First phase clinical trials were conducted in 2017 and more are expected to follow.
RAD-140 has excellent pharmacokinetic properties and is a potent anabolic, as its anabolic-androgenic ratio is 90:1. RAD-140 is a potent androgen receptor (AR) agonist in breast cancer cells with a distinct mechanism of action, including the AR-mediated repression of estrogen receptor1 (ESR1). Phase 1 clinical trials found that RAD-140 inhibited the growth of multiple breast cancer patient –derived xenograft models in isolation. These preclinical data present support for further investigation of RAD-140 in breast cancer patients. The phase 1 clinical trials also showed that RAD-140 increased muscular weight without effecting the prostate. In addition, it lowered lipids (LDL, HDL, triglycerides), without elevation of liver enzymes.
In the fitness community, RAD-140 is seen as one of the latest additions to the lineup of SARMs. The increases in LBM and fat loss are highly appreciated. Recommended dosages of RAD-140 vary from 20- 30 mg once daily and it is used in cycles of 12-14 weeks duration. Because RAD-140 does not interact with the aromatase enzyme and is not liver toxic, no adverse effects are claimed. The half-life of RAD-140 is 12-18 hours.
“RAD140 is able to make the muscles denser and more defined, without increasing body weight. It seems like a great compound for athletes who are trying to increase performance without adding body weight. That’s why RAD140 is a favourite among MMA fighters.
I’ve also noticed that RAD140 has a nootropic benefit of focus and energy. I like to recommend RAD140 if a man says he’s having a hard time finding motivation to workout. It helps increase motivation to work out and train hard.
I’ve found the side effect of anger and irritability can start to occur at dosages higher than 20mg/day. That being said, the benefits also keep increasing as you increase dosages up to 50mg/day. The highest dosage I ever used was 50mg/day and within 48 hours, there was extreme noticeable differences in the mirror. My muscles looked hard as granite and veins were popping everywhere.
Females – I haven’t seen any side effects in women, but I haven’t experimented with high dosages. Females should use 5mg/day.”
- Dr Tony Huge
“RAD140 is very expensive and very commonly faked because of the cost. I never experienced any side effects when using RAD140, other than the aggression side effects Dr. Tony Huge already mentioned.
RAD140 is kind of like the trenbolone of SARMS. It’s similar to s23. S23 leans you out a little bit more whereas RAD140 gives you a bit more strength.
I feel that it’s safe for both men and women. Women can start to get emasculating side effects at 15mg/day. I recommend 5-10mg/day for women and 20mg/day for men.
It’s a good SARM for anyone looking for strength, recomposition, aggression, mass, performance, muscle, and fat loss.”
- Coach Trevor