Sr-9009 is a Rev-ErbA agonist developed by Professor Thomas Burris from The Scripps Research Institute. His initial findings were published in the journal of Natural Medicine showing that sr-9009 supplementation significantly increased weight loss, stamina, and endurance, while lowering blood cholesterol, inflammation, and the risk for developing heart disease. Professor Burris’ study found that the sr-9009 supplementation led to a 50% increased metabolic activity in skeletal muscle, even when exercise was restricted. The sedentary animals developed muscles just like an athlete who had been training. The sr-9009 supplementation also caused resting metabolic rate to increase, even in the absence of exercise.
Sr-9009 supplementation sets off a host of processes in the body by activating the Rev-Erb protein. In particular, sr-9009 increases mitochondria production in muscle cells, increasing metabolism, endurance and strength. Rats give sr-9009 experienced a 50% increment in their running speed. By also enhancing the metabolic rate of the individual, sr-9009 stimulates lipolysis and fat loss.
Sr-9009 may also offer other therapeutic benefits. Recent studies have revealed that daily sr-9009 supplementation reduced plasma triglycerides by 12%, total cholesterol by 47%, plasma non-esterified fatty acids by 23%, plasma glucose by 19%, plasma insulins level by 35%, and pro-inflammatory cytokines by 72%.
Sr-9009 provides a lot of the same benefits as Gw-501516. In fact, the two are often stacked together. The main difference between the two compounds are their half-lives. Gw-501516 has a half-life of 24 hours where as sr-9009 has a half-life of only 4 hours. The short half life of sr-9009 makes it optimal to supplement with immediately before workouts. Sr-9009 is fat soluble so you want to take it with food, such as your pre-workout meal.
The recommended dosage is the same for men and women. If you are using sr-9009 by itself, you will want to take 10mg 3 times per day, spread out as much as possible. The easiest way would to be to take 10mg at breakfast, lunch and dinner. If you are stacking sr-9009 and Gw-501516, then you would take 20mg of Gw-501516 with breakfast and 10mg of sr-9009 with your pre-workout meal.
“I haven’t had a chance to do too many experiments with SR-9009 yet but I did inject 50mg and got blood work done the next day. It massively improved my cholesterol. It’s hard to say if it can be attributed solely to the SR-9009 but it seems to have the potential to repair cholesterol side effects from steroids. I will be conducting more sr-9009 experiments in the near future. Stay tuned.
One side note – I’m worried that the oral form is not absorbable.”
- Dr Tony Huge
“I really like it. I don’t like the oral version. The oral version has only a 2-3% bioavailability. I saw the most dramatic improvements in cardio with injectable SR-9009 then any other SARM. It helped preserve my muscle mass when fasting and doing fight training better then Gw-501516. SR-9009 increases number of mitochondria, and fixes broken mitochondria. Increase in mitochondria in muscle tissue have the direct relationship to increasing strength, endurance and muscle size.
The oral version is useless. The dosages needed would cause stomach distress. I’ve experimented with injectable sr-9009 dosages as high as 50mg/day. 10 to 25mg/day is the dosage I recommend for the average person.”